Most of you Class A vet clients already know about all these common OTC pet meds. Nonetheless, I offer ‘em up here because maybe (just maybe) there’s something I can add to your basic understanding of these medications, their indications and contraindications.
So without any further ado, here are my top five, peppered with disclaimers about always asking your vet first before using ANY drug. Remember, O-T-C does not mean S-A-F-E!
1-Pepcid AC (famotidine) and Tagamet HB (cimetidine): These stomach drugs are great for pets when gastric juices get flowing into overdrive. Mostly used in dog medicine for simple gastritis (stomach inflammation) as a result of any number of tummy insults (self-inflicted through “dietary indiscretion” or otherwise), it hinders the body’s production of GI tract acids.

Dosages depend on size, other drugs administered and your pet’s general condition. Always check with your vet first to get the right dose and the go-ahead.
2-Aspirin: Though I don’t use aspirin much for pain (why use a less potent, more stomach-harming drug when you’ve got safer, more effective ones available?), I still rely on it for dog pain when a client is far away and has nothing else available. As a rule, I never recommend the use of aspirin for more than two days in a row. If your dog still has pain, you need to get to your vet for a look-see and more appropriate meds.
NOTE!: Drug interactions with aspirin are not uncommon so don’t automatically assume it’s safe to give!

Some kitties will also do well with aspirin (in very small doses) when they have heart murmurs. Blood clots can come about as a result of feline heart diseases. Aspirin hinders clot formation so if your cat has a heart murmur due to “hypertrophic cardiomyopathy” or an undiagnosed heart ailment, aspirin may be in order to lower the likelihood of a catastrophic “saddle thrombus.”
Ask your vet, internist or cardiologist about this before using it as other drugs your cat may be taking may interact adversely with it! And always discontinue aspirin for several days before surgery (it’s true, sometimes we vets forget to tell you these things so it’s always good for you to know).
3-Artificial tears (Genteal, et. al.): I love artificial tears for minor eye irritations—it’s the ultimate do-no-harm eye treatment.

Most of the time, very mild conjunctivitis (slight weepiness or redness around the eyes) will clear right up with a few days of simple soothing with extra tears. But if you’ve got white, yellow or greenish discharge, if extreme redness or swelling is present, or if the eye is painful (obvious with winking or closing or the eye), skip this step and head to the vet immediately.
Remember, even a day is too long to wait with a painful eye!
4-Benadryl (diphenhydramine): This is a great, easy-going drug for a common case of the itchies or at the first sign of hives. I use it pretty liberally in my practice but it’s not without its side-effects.

Be warned: some pets will feel its sedative effects more than others, especially pets on mood-altering drugs and/or seizure medication. And also note: The dosages can be significantly different than for humans, so don’t just pop a pill down. Call first and ask if it’s OK.
5-Neosporin and other antibiotic gels: Minor cuts and abrasions love this gel. Problem is, overuse can hinder the body’s own superficial defense mechanisms. I tend to recommend it for the slightest of scrapes applied in a very light coat onto clean skin for only a day or two—that’s all it should take. 
Other issues with these ointments: People tend to buy fancy ones with tetracaine and other ingredients (which can hinder healing for some wounds). And pets like to lick wounds, especially when their attention is drawn to them by smelly gels. In these cases they’re contraindicated.
6-Hydrocortisone sprays, gels and creams: Standard OTC hydrocortisone sprays and creams can be a life-saver in a pinch when itchy red patches and hot spots result. But you should know that the sprays can be stingy (they typically contain alcohol). And the gels and creams are great—unless they attract unwanted attention to the licky or itchy-spot.

As always, let me know if you have others you can't live without...
Add Comment34 Comments
Freaky timing. Husband and I were just discussing starting our 14 year old lab mix on aspirin for his increasing joint pain. Husband went to go get some from the medicine cabinet and I turned to your blog for my daily fix. Thanks for this post - we'll take him to his vet now.
Fat Doctor February 23rd, 2008 08:45:00 PM
Glucosomine with chrondroitin from Wal-mart was a lifesaver for my dog when he got arthritis. Easier on the tummy than asprin too.
Marie February 23rd, 2008 10:09:00 PM
I want to second the "less harmful, more effective" comment about aspirin. As humans, we tend to think of it as a fairly safe drug, it's harder on dogs than us. I know a lot of people who give their dogs aspirin for aches and pains from overdoing it on unusual weekend activities, etc; when I asked my vet about this, she gave me a prescription for Rimadyl to use as needed.
Juli February 23rd, 2008 11:48:00 PM
You mention Benadryl being more likely to cause drowsiness when mixed with anti-seizure meds. Don't sedating antihistamines lower the seizure threshold and therefore could be a problem with epileptic pets anyway?
Alison February 24th, 2008 01:46:00 AM
I use benadryl (25 mg for my 85 lb. Labs) on occasion for allergic reactions. In the case of bee stings I add 150 mg of Tagamet (again, for dogs their size), as it is a histamine antagonist, and tends to prevent the re-release of histamine and subsequent recurrence of hives after the benadryl wears off. And in high doses and overdose, it can cause agitation rather than sedation. I prefer plain bacitracin ointment over neosporin for minor wounds, as I don't care for the combination ointments such as Neosporin (more ingredients, more chance for an adverse reaction to one of them). And I always keep a bottle of plain normal saline eye-wash on hand if needed to flush debris from eyes, as well as a large bottle of sterile normal saline solution for cleaning minor wounds.
Shellie February 24th, 2008 01:52:00 AM
Oops--above should read "in high doses and overdose, benadryl can cause agitation rather than sedation".
Shellie February 24th, 2008 01:55:00 AM
Great info...here's one more: Immodium! It works wonders for that occasional bout of diarrhea. As with all the others, see your vet pronto if it doesn't clear up quickly but I always keep it on hand for my Lab.
Anne February 24th, 2008 08:49:00 AM
Shellie: In low doses, too, Benadryl can result in agitation for some dogs--and people!
Alison: Your point was an interesting one. I've heard conflicting reports on the use of diphenhydramine in epileptics lowering the seizure threshold so I did a little research. While one neurologist acknowledges the possibility, he still uses it, noting that it's not a common enough occurrence to be of major concern. Another vet, a boarded pharmacist and a consultant on the Veterinary Information Network, confirms its almost universal safety in seizure patients, despite the possibility of increased sedation in pets on phenobarbital. Still, any owner of a seizure patient would do well to *always* check with their vet on this, especially if we're talking about a hard-to-contol seizure case.
Dr. Patty Khuly February 24th, 2008 09:34:00 AM
Anne: On the Immodium thing. I'm not a big fan in general. That's because Immodium alters gut motility. Nomal gut motility (movement, as in peristalsis, etc.) is an important part of normal healing. But I do have a couple of caveats: If it's mild of if the onset is sudden and the pet is otherwise healthy with no history of hemorrhagic gastroenteritis or pancreatitis (or other major GI issues), one or two doses is almost always OK. Furthermore, if you have used it like this safely in this particular pet forever, then you're likely OK, too. I'll also use it in chronic diarrhe cases as an adjunct to other meds in very specific cases.
For diarrhea I like to start with simple, do-no-harm approaches like canned pumpkin and a bland diet (in large dogs I'll often tell my clients to skip a day of food, too). In the next post in this series, I'll also be discussing probiotic suplements, an increasingly important tool in my anti-diarrhea arsenal.
Dr. Patty Khuly February 24th, 2008 09:44:00 AM
Per veterinary advice, I administered Benedryl to my Sealy with IVDD, specifically for its sedative effects-----I found it a lifesaver for both me and her. Otherwise, she was in hysterics wanting freedom and activity, instead of the mandatory crate rest and confinement.
Barbara A. Albright February 24th, 2008 11:58:00 AM
I use a mixture of 3/4 witch hazel and 1/4 aloe vera gel, with an optional few drops of lavender oil added to 2 oz of the mixture. I use this mixture to soothe itchy spots, clean small wounds, and to clean ears. My dogs always act as though it feels good. It also has some antibacterial effect, especially with the added lavender oil.
Thayers sells a combination of witch hazel and aloe, but I usually just buy both and mix my own. I always have a bottle of the mixture on hand and use it often.
Mary February 24th, 2008 12:51:00 PM
Raising several French Bulldogs and organizing outdoor events, I keep Baby Benadryl in the form of tongue strips handy, in case of emergencies only... Have never had to use them, so far - thankfully - but can take comfort in being somewhat prepared.
Tatiana February 24th, 2008 12:55:00 PM
3) Which type of artificial tears are the best? Do I want ones that are plain saline and nothing else, or do I want with some additive or other?
4 & 6) Can benadryl or hydrocortisone be used with non-mammals? I know birds often pluck their feathers, and sometimes it's due to dry skin (more commonly due to mites or psychological problems - i.e., boredom), and it seems these could be a useful treatment if irritation due to dry skin were the cause of the bird plucking.
zandperl February 24th, 2008 01:52:00 PM
zandperl: Must say I have no idea. I looked it up in my online drug handbok and on VIN (the Veterinary Information Network) and found no references to these products' topical use (or oral use in the case of Benadryl). Maybe our South African wildlife rehabber will chime in and save my butt on this one.
Dr. Patty Khuly February 25th, 2008 08:45:00 AM
Oops--the artificial tears thing: saline is great for flushing the eye when mild redness results from a possible foreign body, but artificial tears (like the Genteal product) is what I use for simple soothing.
Dr. Patty Khuly February 25th, 2008 08:47:00 AM
Tatiana: What a great idea! I usually travel with an epi-pen but then I'd get a pass if I needed to use it. I can't imagine anyone being very happy about a non-vet wielding powerful meds in the puppy park.
Dr. Patty Khuly February 25th, 2008 08:50:00 AM
* Kaolin-Pectin for stomach upsets
* Glycerin suppositories for constipation
* Zymox Otic - amazing treatment for early stage ear crud
* Gold Bond Powder for itcy, irritated skin in larger areas like bellies and thighs
* Bag Balm for dry pads especially in winter
SmartDogs February 25th, 2008 11:35:00 AM
Pepcid a/c is also frequently used for ferrets with GI issues. Getting a pill in a ferret is pretty much impossible, but you can dissolve the correct dosage in a little water and administer it by syringe. They don't mind the taste too much, and it's such a small amount it's easy to get into them.
regina February 25th, 2008 12:20:00 PM
I had been wondering if Loratadine (10mg) daily would be an effective preventative treatment for a basset who is prone to allergy induced ear infections. He is currently on a daily dose of 1 Medrol, 4 mg per day.
Spring is already in Texas, and his ears already are starting that tell tale smell. I battled these infections all summer last year, and my poor guy suffers with them constantly. Any other OCM's that might prove effective?
Also have a pom mix who had an enlarged heart due to allergies. She has done well on Benanzepril and Tamiril P, and her heart has somewhat returned to it's normal size. Springtime has her congested too though. Would an allergy treatment be of benefit to her as well?
Brenda February 25th, 2008 02:31:00 PM
I use benadry for allergies in my terrier.
cindy February 5th, 2009 07:26:42 PM
Doolittler, I just love your website and blogs!! Thanks for visiting us at http://vetwisdomcafe.com/. This is a really good list for all pet owners to have (after all, they're just like kids and often get into all sorts of trouble)!
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for joint pain Merisytalstoliate is good to its a smaller molicule than gulcosomine
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