Vet School 101 Hip dysplasia in dogs: Thoughts on incidence, treatment and prevention

October 19th, 2008  

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You're darn right it is misunderstood, including by naive breeders! My personal story: Although hip dysplasia is not even considered on the list of hereditable disease in the Sealyham Terrier, I suspect that this or other like-is. It is only "recently", and after years and probably a dozen x-rays, that one reviewing vet pointed out arthritis in Pearl's right hip! I looked closely and did NOT like what I was looking at.Fortunately, she only produced 4 offspring, non of which went on to be bred.

I got the inkling of this possibility, when a breeder showed my the x-ray of a 5 month old that went lame and had to be crate-confined. This had absolutley no connection with IVDD, which we do know about. Then after the age of 3-4 yrs., an owner of one of Pearl's pups was diagnosed with, yep....a bad hip! I thought surely that was a mistaken diagnosis & was really IVDD.

Why on earth, it never came up years ago, despite the same view x-rays, I won't know unless retrieved & reviewed.

The moral of my story? Little dogs can have this too and it may not be on the list of prevalence.
Scottish Terriers are known to have Legg-Perthes that has to have surgery early on, and perhaps a lesser form is possible? But along with screening for luxating patellas, it should be done.
(apparently some dogs are diagnosed with luxating patellas that don't really have them either)

Barbara A. Albright/New Hampshire October 19th, 2008 03:56:00 PM

Patty - Can you talk about the efficacy of PennHIP and OFA in determining just who is at risk of hip dysplasia? What can people who are looking to buy (or adopt) a puppy do in the way of assessing the possibility that there are signs of hip dysplasia? What about cats and HD?

Alex October 19th, 2008 04:37:00 PM

It sounds like the word isn't getting out to the general public. In our insulated little show/performance world, screening for hip (and often elbow) dysplasia is second nature. Most of the breeders I know wouldn't dream of breeding a dog - or breeding to a dog - who didn't have at least a "Good" rating. But it's very, very rare for a person looking for a pet puppy to ask about hip dysplasia screenings. Or any other health screenings, for that matter. I think they just don't know! But then again, considering the vast numbers of people who obviously haven't even heard about the pitfalls of buying a puppy from a pet store or from an anonymous online breeder, I guess it shouldn't be so surprising that most people don't know enough to ask about health screenings.
But the truth is, that if puppy buyers DID start asking about them - and asked to see the documentation - then you better believe that even the commercial breeders would start testing for hip dysplasia and other diseases.

Barb October 19th, 2008 05:16:00 PM

Barb: I hope you don't mind a bit of clarification. While most parent pure-bred clubs have its list of health screenings, and those to be CHIC certified, there isn't any breeder that possibly screens for every hereditable disease known, and even those that can be screened as "affected" and not bred, do not assure that recessive gene match up in non-affected/carrier sire/dam combinations.

Until we have genetic screenings for every disease and every breed, no one can guarantee with 100% certainty anything! An ethical breeder can only do their best in decreasing risks numerically and taking responsibility once a carrier is proven.

Barbara A. Albright/New Hampshire October 19th, 2008 05:50:00 PM

Alex: Great questions. I'm working on a follow-up post on hip dysplasia diagnosis and treatment which will specifically address costs. I'll include something on PennHip and OFA, for sure. On cats--we're starting to see (recognize?) more of this. My local referral practice already does hip replacements on cats.

Dr. Patty Khuly October 19th, 2008 07:28:00 PM

Timely topic, I'm taking two two year old toy fox in on Tuesday for OFA elbow, hip(LCP and HD) patella and thyroid.
And two old bulldogs for OFA trachea.
And a lighter wallet.

Next month is the pilgrimage to the opthalmologist for CERF

JenniferJ October 19th, 2008 08:25:00 PM

I think that many people don't know about the health screenings a good breeder will take. I also think that many people don't see the point in paying $700 for a puppy when they can get one from the paper for $200. Many people also get offended when someone checks them out in depth- I see that all the time at the Humane Society.

We learned our lesson. 15 years ago we brought home our puppy after answering an ad in the paper. He had a wonderful temperment- but he also had allergies and severe hip displasia. In the end that is what took him from us. He went down and couldn't rise on his own and despite our best efforts didn't improve enough for it to be fair to keep him with us. It was heartbreaking that after around age 6 I had a dog I had to carefully supervise- limit walk intensity, no jumping off things etc. or he would hardly be able to walk the next day.Heartbreaking to lose him to something that could have been prevented if someone had cared enough in the beginning.

Amanda October 20th, 2008 12:47:00 AM

When I first got into showing and breeding English Setters in the mid 70's, I think probably two out three English Setters were dyplastic. On OFA's list for the breeds with the worst dyplasia we were number three right behind German Shepards and Saint Bernards. I am proud of what English Setter breeders have accomplished by choosing to breed dogs with OFA certified hips. We are now number 48 with 16.8% dyplastic and 9% rated OFA Excellent hips. I have a hip xray collection in my closet on every dog I have every xrayed. I get them out to compare with current dogs' xrays. In my 32 year breeding program, I can tell you that my hip xrays today are better than prior dogs. Before my dogs received mainly Goods with an excellent thrown in here and there. Now my average ratings are what I call Good plus with a generous number of Excellents. I am proud to offer pets to families that I know will never suffer the debilitating effects of hip dyplasia. Dr Khuly, breeders can make a difference.

Diane October 20th, 2008 02:40:00 AM

In terms of breeding practices -- how can "we" have reached the limit in controlling genetic hip disease when only a TINY minority of purebred dog breeders do ANYTHING to screen breeding stock?

In other words, the experiment has never been conducted in this country. How could it have failed?

One has to look at very controlled centralized breeding programs to get an idea of how to make genetic progress (and what not to do). Some of the guide dog programs, for example, which have had their ups and downs. That said, "controlled" and "centralized" are not things that Americans do well.

Some of the European systems, especially the ones that assign breeding value scores to animals that are based not only on their own hip scores, but on those of their parents, siblings, and get, are quite interesting. If only cheating could be eliminated and all data captured from non-breeding animals -- then control strategies could go forward with the best possible information on an entire gene pool.

Certainly, "progress" will be localized and erratic until the "consumers" of dogs insist on due diligence from breeders.

When many buyers can't be bothered to choose an appropriate kind of dog for their lifestyle, or determine that their pups' parents are not irreparably vicious -- it's going to be a long slog on the consumer education front before we get around to genetic hip health.

H Houlahan October 20th, 2008 04:33:00 AM

H Houlahan: Agreed. It just seems that the degree of interest in breeding good hips into dogs (and fixing them when they're truly horrible) has reached a steady-state. Or worse--it's succumbed to the knowledge that drugs will give owners a way out. Is the vet establishment unwittingly promoting poor hips by offering reasonable options for long-term pain control? I think this is an interesting issue we rarely discuss.

Dr. Patty Khuly October 20th, 2008 08:42:00 AM

Ah! I do see your point. I wonder if OFA and PennHIP stats are available that could verify or falsify the sense that the percentage of breeders using hip screening is not increasing over time any longer? It would be hard to parse out which animals are being radiographed as breeding prospects, which to provide sibling/progeny data, and which because the non-breeder owner is checking for the animal's individual benefit. In some cases, all three reasons apply.

But I suspect that you are right that, species-wide, the number of breeders using hip screens to cull from the breeding program, and the number of savvy buyers who understand the process and insist on it, has reached saturation.

I happen to own an uncommon breed where, because of social pressure within the breed club and breed community, we appear to be making some progress.

We are fortunate to have the input of people who actually understand population genetics and conservation breeding practices, to help us dodge other bullets and maintain perspective. We are also fortunate that, thus far, HD is the only genetic condition that is of wide concern in the breed -- we aren't balancing selection for six or eight really bad genetic disorders before we ever get around to the question of whether the dog is generally a good specimen. We are extremely fortunate to be free of selection for show wins almost across the entire community.

We are unfortunate that pups of this breed, indifferently bred from underaged parents who have not been evaluated for either hip health or working qualities, are cheaply available. Like, couple hundred bucks, or trade for a used Nintendo cheap. That means that the market is depressed for the $500 pup (expensive in our breed) whose mature working parents passed their hip screens, from bloodlines proven for both work and healthy hips, and on a contract that requires such niceties as an acceptable hip score and a minimum age before the buyer breeds. So maybe the best breeders produce fewer litters than they should, while the slipshod ones carry on.

Buyer education is our best recourse, and I do see some signs that it is having an effect. I've seen some truly jaw-dropping examples of *resistance* to buyer education, too, though, that boil down to "What the hell, this one is cheap, I'll take my chances and I'll be a 'breeder' in ten months myself."

As for better pain management leading to complacency in breeding -- I sure hope not. I don't know if you are right. Managed pain is not no pain.

From my position, the great non-genetic advance in handling all forms of arthritis has been the advent of nutraceuticals. I'm convinced that Glyco-flex gave my first SAR dog (GSD from working lines and hip-cleared ancestors, OFA Moderate per radiograph at 27 months, but asymptomatic until middle age) several years of working life she wouldn't have otherwise had, and several years of happy retirement as well. (Was cancer got her, not her joints.) If a dog does not develop HD or osteoarthritis because of a dietary supplement, that's not pain management, that's disease prevention -- and makes me think harder about our culture-wide practices of *feeding* rather than breeding.

All my dogs -- who are all radiographically sound -- get a glucosamine supplement all their lives now.

H Houlahan October 20th, 2008 11:12:00 AM

Dr. Khuly, I doubt that current advances in medication or surgery has had any effect at all on HD screenings. And I doubt that consumer awareness or demand has had any either. Truthfully, it is breed club demands or strong suggestions that have the greatest influence. And most clubs pick out two or three that can be screened for.

Unfortunately most can't be screened for, it is only when an affected pops up, that carriers become known. And worse still, are the many afflictions that show up "late" or beyond prime breeding age. That's where supported genetic research is so important. It took over a decade to discover vWD gene in the Scottie. We hope to find genes for Cerebellar Abiotrophy and Transitional Cell Carcinoma. Lofty goals, but one which the club is serious about.

OFA results are posted or an entire printing can be ordered for a specific breed for fee. (My Sealyham is the oldest listed "Cerf"'d at 14 yrs. 1 mo.)

Barbara A. Albright/New Hampshire October 20th, 2008 07:35:00 PM

I wanted to get in earlier on the conversation, but here are some things that are worth considering:

* HD is controlled by multiple genes, it's not easy to breed out and it has complex heritance.
* HD is not strictly genetic, activity influences expression and sadly, in Border Collies, all the things we love to do increase expression.
* OFA is useless. Not only do the same x-rays lead to different determinations, the results are too subjective and aren't helpful in making breeding decisions.
* PennHIP which is superior and objective, is also expensive. To answer an earlier question, PennHIP will tell you (1) the measured hip laxity, (2) where your dog falls within all <same breed/age> dogs tested, and (3) for each measure how likely it is for dogs dogs to develop HD.
* Hip testing is not prevalent at all.
* HD appears to be very prevalent.

When you combine (prevalent) with (complex heritance), this is a problem that can't be solved with limiting the breeding pool even more. It's not a no-brainer like "don't breed merle x merle" or monitor carrier status and cull affected puppies with single gene diseases.

I personally believe that this is a problem that won't be solved until we have inexpensive gene therapy.

No one has an incentive to increase the prevalence of this condition, unlike the diseases associated or linked with rare colors or intentional diseases (like dwarfism, etc) that are desired. But frankly, it's not serious enough to warrant pruning the gene pool even more.

If you want to make that argument (not a bad one, per se), I think we would have to also argue that pugs should cease to be bred, along with bull dogs, American German Shepherds, Dobermans, and a slew of other breeds that have a near universal rate of crippling conditions.

Christopher Landauer October 21st, 2008 11:30:00 PM

Christopher: I'm intrigued by your assertion that hip disease won't be controlled until we have an easy, inexpensive way to screen pets. It meshes well with my view but I never thought to think of it in terms of testing. Because of the way HD is inherited, however, I think this kind of genetic testing is a far-off possibility.

I wrote a post on bulldog breeding recently. You might have missed it. Again, I seem to be in agreement with you:
http://www.dolittler.com/index.cfm/2008/9/30/dog.c...%20bulldog.cruelty.inhumane.welfare

Dr. Patty Khuly October 22nd, 2008 08:49:00 AM

My vet surgeon boyfriend (and Dolittler consultant), Dr. Marc Wosar, read this post yesterday and disagreed with my intimations that surgery was not a good option.

While I will amend the post to reflect his views (which I agree with), I want to explain that I didn't mean to suggest that hip dysplasia was not eminently treatable via surgery. Surgery is in fact an *excellent* option with a high degree of success--it just happens to be an expensive one.

I was simply trying to point out that it's one most pet owners won't accept--and that's confusing to me. While so many people are willing to pay for cruciate disease surgery (in dogs' knees) it seems hip dysplasia doesn't get the same consideration.

Mea culpa for the lack of clarity...will fix...

Dr. Patty Khuly October 22nd, 2008 08:55:00 AM

Dr Khuly, in my opinion, you touch on why I believe more people don't opt for surgery. Being more often on the consumer/client end of the pet industry, but with also more than average pet experience including shelter adoption counselor among other things, I think I can offer one pretty informed opinion on why this is. Two main factors: the options available for maintenance of the condition, and how common it has indeed become.
I think many/most large breed dog owners ARE aware of HD. Around the time large breed puppy food formulas started becoming popular, awareness increased. But the fact that in older dogs the symptoms are similar to what many laypeople expect from old age, combined with how common it's become, has created a stage for accepting what seems an inevitable part of large dog ownership (although as shown here it's not just large breeds).
Add to this that any time a medical condition is involved with an option for surgery and an option for management through medication, most people are not going to go the surgery route. Surgery, to many people, is a last-option for their own health/treatment. It seems even more extreme for pets, to some. Finally, if many people don't know the full extent of the pain their animal is in, they don't/won't make that very subjective decision of knowing when the point has been reached to elect for surgery.
Speaking as a client, without the gobs of experience and perspective that you and any vet have (and therefore maybe being a bit idealistic), I think it is the vet's responsibility to stick to their guns and make clear what they think is the most ideal treatment for the animal, regardless of the reaction from the client. I know that's what I want, yet sometimes my vet (s) haven't given me the benefit of the doubt that I will do what they consider is ideal but maybe not realistic for many clients. Of course many people still won't opt for the best/harder/more expensive treatment. But many will that might not have otherwise. This is something I am often confronted with and contemplate about, and would love to hear you opinions, Dr. Khuly.

Erin October 22nd, 2008 11:35:00 AM

Erin: I think you're right. I think more vets need to stick to their guns and offer the right choice the first time around. Problem is, I don't believe all vets do. Part of me wonders if it has to do with the risks involved in surgery or with lack of veterinary education on the true state of the art when it comes to modern hip surgery. But the cynical me also wonders if it has to do with financial issues: If we manage our hip disease patients with medication and Adequan injections and physical therapy we provide we make more money. If we send them to the surgeon and to fix them how much income will we lose?

It's perhaps way too cynical a thought but, nonetheless, I'm sure it affects how some vets treat these cases. Is it a rampant problem? I don't think so but it deserves some consideration.

Dr. Patty Khuly October 22nd, 2008 12:22:00 PM

 

I am so frustrated with breeders!  My St. Bernard is 8 months old, and I just had to pay $2000 for his surgery.  The breeder refused to return my emails/phonecalls.  The recovery from this surgery is just heart breaking because he is still a baby!  He is doing much better, but now the other leg needs to be operated on.  It just angers me that breeders are using animals a income, instead of being concerned about the dog.  It is like a mother who is told her chances of having a Down Syndrome baby are so high, however she continues to have children.  Not only does it put the dog in pain, but also hurts teh family who has learned to love the animal as part of thier family.

Brooke December 7th, 2008 05:09:33 PM

My doughter just found out her dog has Hd his vet sugeasted surgey gunner is 1 year old he said he wanted to remove the head of joint i was on the computer trying find any information on surgery????? how succesfull is this what is recovery rate he is 85lb's already my concern is will he ever recovery hs is not over weight very thin just big?

pat December 29th, 2008 05:24:16 PM

This message is in response to Brooke's entry. I'm curious if she originally purchased her St. Bernard from a 'reputable breeder'? Any reputable breeder would have no problem returning phone calls or emails. Any pubred, registered dog comes with a guarantee. If she wasn't willing to originally pay $2000 for her puppy, which would have guaranteed her the parents had been tested, and wanted one cheaper, from a online breeder pretty much puts her in the same league as them. Paying the money up front to a 'reputable breeder' helps give you a little protection against the incidences down the road. She possibly helped aid the online breeder with their income. And is now sorry in the end.

Sherri December 30th, 2008 11:11:29 PM

i really need to know if i can aplly any physical therapy for my 9 years old german shepared who have recently got hip dysplesia please reply

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